SB 204990

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SB 204990 是一种有效且特异的 ATP 柠檬酸裂解酶抑制剂。

SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.

SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels.

SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels.

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Endocrinology/Hormones

ATPase

ACLY

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154566-12-8

389.27

C18H22Cl2O5

>98% (HPLC)

DMSO:100 mg/mL (256.89 mM);H2O:10 mg/mL (25.69 mM; Need ultrasonic)

O[C@](CC(O)=O)(C[C@@H](CCCCCCc(ccc(Cl)c1)c1Cl)O1)C1=O

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(-20℃)

With Ice Pack

≥ 2 years